Alternative Title: iPS cell Induced pluripotent stem cell (iPS cell), immature cell that is generated from an adult (mature) cell and that has regained the capacity to differentiate into any type of cell in the body. Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription hucks.xyz by:
Adult Pluripotent Stem Cells (APSCs), first discovered in mice in , and then humans in by Professor Ratajzcak at the University of Louisville, are a spectrum of cells of similar size and the potential to form any other cell in the human body. Some types of APSCs are referred to as “Very-Small-Embryonic-Like Stem Cells (VSELs), Multi-Lineage Differentiating Stress-Enduring Cells . Pluripotent adult stem cells, which reside as a subpopulation within adult stem cells, can be easily isolated by pluripotent cell surface markers, such as SSEA-3, SSEA-4 and CD49f. Moreover, pluripotent adult stem cells can be characterized by their ability to differentiate into cells of 3 germ layers (ectoderm, mesoderm and endoderm) as well as by the chimera formation in xeno-transplanted hucks.xyz: Tsz Kin Ng, Daniel Pelaez, Veronica R. Fortino, Jordan Greenberg, Herman S. Cheung.